Tumour movement – Shift in volume, position and shape, during and in-between therapy sessions.

Radiation today

Radiation is still emitted into a black box - resulting in severe side effects

Whereas the possibilities for performing high-precision radiation therapy have improved, radiation therapists are still left with a black box problem.

Current imaging techniques are not sufficiently refined to provide information on the exact positioning, shape, and volume of a tumour during delivery of radiation to treat the cancer. This is due to the anatomical changes of the tumour in-between treatment sessions, as well as the patient’s breathing and other body movements during a treatment session. Consequently, radiation might be erroneously emitted to healthy tissue, and/or will not efficiently be covering the entire volume of the tumour.

Emitting high loads of energy to healthy tissue might cause severe side effects. This can result in nausea, hair loss, incontinence, impotence, hearing loss and the risk of developing other types of cancer. On the other hand, insufficient radiation coverage of the tumour will decrease treatment efficacy.

Our technology

Opening the black box provides competitive advantages

– an advanced plug-in software solution to enhance the performance of radiation therapy

MaMa-K is a proprietary software solution that allows the radiation therapist to gain visibility into the black box surrounding the tumour and knowledge of size, shape and volume of the tumour and surrounding tissue. This allows for more precisely and adaptive radiation.

A digital twin of the patient

Based on AI-processed input from standard imaging and sensors, MaMa-K shapes a high-definition digital 3D image of a specific patient, a digital twin of the patient – displaying anatomical changes in the tumour and surrounding tissue. This patient-specific digital twin will serve as a decision base, starting from the first treatment fraction. This makes it possible with adaptive treatment –throughout the entire treatment, which normally consists of 4–20 fractions.

The software solution may also be used to compile post-treatment reports elucidating the actual distribution of a previous radiation dose.

Importantly, MaMa-K requires no specific new hardware as it can be plugged into established radiation therapy equipment.

A strong IP position

The MaMa-K software solution is covered by three patent family applications with priority dates ranging between 2018 and 2022. Two of them have already been approved in several important geographical markets, such as the US, EU and Japan.